Veterinary Highlights: Reversing Type 1 Diabetes in Dogs without Insulin?

Insulin is a hormone that regulates the blood levels, distribution to cells, and storage of glucose. Diabetes is a disease in which this regulation breaks down. Too much glucose remains in the blood, while the body cells are starving for energy.

Veterinary Highlights: Reversing Type 1 Diabetes in Dogs without Insulin? IU Therapy

Dogs can get one of two types of diabetes. Type 1 diabetes describes glucose regulation break down due to insufficient insulin production.  Type 2 is known as insulin resistant diabetes, meaning there is plenty of insulin but the body cells do not respond to it. Dogs mostly suffer from Type 1.

The treatment, logically, consists of supplementing the deficient insulin. That is both straightforward and complicated. Firstly, it involves needles. Secondly, perfect regulation can be tricky. In a healthy dog, the insulin levels respond directly to the glucose levels and cells’ need for energy. But both of these things are highly variable.

What if there was a treatment option that would both eliminate the need for needles as well as restore the natural feedback regulating insulin levels?

Purdue University, in collaboration with the Indiana University School of Medicine, is working on a new way to implement the transplantation treatment.

It’s not a new idea, but this method is trying to address previous challenges. Islet transplantation was invasive and much of the transplanted islets were destroyed by the immune system. This time, they’re experimenting with injecting a mixture of islets and collagen under the skin, instead of liver.

In mice, this treatment seems to reverse Type 1 diabetes within 24 hours and maintains insulin independence for 90 days.

So that’s all pretty interesting and I am curious to see where it goes.

Source article:
Purdue, IU Therapy for Canine, Human Type 1 Diabetes Holds Promise

Categories: Alternative treatmentsConditionsDiabetesIslet cell transplant

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Jana Rade

I am a graphic designer, dog health advocate, writer, and author. Jasmine, the Rottweiler of my life, was the largest female from her litter. We thought we were getting a healthy dog. Getting a puppy from a backyard breeder was our first mistake. Countless veterinary visits without a diagnosis or useful treatment later, I realized that I had to take Jasmine's health care in my own hands. I learned the hard way that merely seeing a vet is not always enough. There is more to finding a good vet than finding the closest clinic down the street. And, sadly, there is more to advocating for your dog's health than visiting a veterinarian. It should be enough, but it often is not. With Jasmine, it took five years to get a diagnosis. Unfortunately, other problems had snowballed for that in the meantime. Jasmine's health challenges became a crash course in understanding dog health issues and how to go about getting a proper diagnosis and treatment. I had to learn, and I had to learn fast. Helping others through my challenges and experience has become my mission and Jasmine's legacy. I now try to help people how to recognize and understand signs of illness in their dogs, how to work with their veterinarian, and when to seek a second opinion. My goal is to save others the steep curve of having to learn things the hard way as I did. That is the mission behind my blog and behind my writing. That is why I wrote Symptoms to Watch for in Your Dog, which has turned out being an award-winning guide to dog owners. What I'm trying to share encompasses 20 years of experience.

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